polymerase chain reaction

noun

: an in vitro technique for rapidly synthesizing large quantities of a given DNA segment that involves separating the DNA into its two complementary strands, using DNA polymerase to synthesize two-stranded DNA from each single strand, and repeating the process
abbreviation PCR

Examples of polymerase chain reaction in a Sentence

Recent Examples on the Web
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Most flu tests, whether rapid or the PCR tests (polymerase chain reaction), are coming back as positive for flu A and not flu B. Flu A is more common and more common in adults. Nicole Villalpando, Austin American Statesman, 2 July 2025 Most tests available today to see if people have the virus are conducted using reverse transcription polymerase chain reaction (RT-PCR) technology. IEEE Spectrum, 29 May 2020 The genetic sequencers, polymerase chain reaction machines, and mass spectrometers that can detect a broad range of pathogens — 40 bacteria and 15 viruses — must be validated before they can be used with samples collected from patients. Paul Sisson, San Diego Union-Tribune, 2 June 2025 In last week’s announcement, World Boxing said all athletes over the age of 18 will have to undertake a PCR (polymerase chain reaction) genetic test, which can be conducted by a nasal or mouth swab, saliva or blood. Reuters, CNN Money, 4 June 2025 See All Example Sentences for polymerase chain reaction

Word History

First Known Use

1985, in the meaning defined above

Time Traveler
The first known use of polymerase chain reaction was in 1985

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Cite this Entry

“Polymerase chain reaction.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/polymerase%20chain%20reaction. Accessed 20 Aug. 2025.

Medical Definition

polymerase chain reaction

noun
: an in vitro technique for rapidly synthesizing large quantities of a given DNA segment that involves separating the DNA into its two complementary strands, binding a primer to each single strand at the end of the given DNA segment where synthesis will start, using DNA polymerase to synthesize two-stranded DNA from each single strand, and repeating the process
abbreviation PCR

More from Merriam-Webster on polymerase chain reaction

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